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Publications

Peer-reviewed publications relating to the development and implementation of the CRADLE device and the CRADLE trials

2019

Vousden N, Lawley E, Nathan HL, Seed PT, Muchayiwa FG, Goudar S et al.  Effect of a novel vital sign device on maternal mortality and morbidity in low-resource settings: a pragmatic, stepped-wedge, cluster-randomised controlled trial. Lancet Glob Health 2019; 7: e347–56

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Vousden N, Lawley E, Seed PT, Gidiri MF, Goudar S, Sandall J, et al. (2019) Incidence of eclampsia and related complications across 10 low- and middle-resource geographical regions: Secondary analysis of a cluster randomised controlled trial. PLoS Med 16(3): e1002775. https://doi.org/10.1371/journal.pmed.1002775

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2018

Vousden N, Lawley E, Nathan HL, Seed PT, Brown A, Muchengwa T, Charantimath U, Bellad M, Gidiri MF, Goudar S, Chappell LC, Sandall J, Shennan AH; CRADLE Trial Collaborative Group. Evaluation of a novel vital sign device to reduce maternal mortality and morbidity in low-resource settings: a mixed method feasibility study for the CRADLE-3 trial. BMC Pregnancy Childbirth. 2018 Apr 27;18(1):115. doi: 10.1186/s12884-018-1737-x. PMID: 29703254

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Nathan HL, Duhig K, Vousden N, Lawley E, Seed PT, Sandall J, Bellad MB, Brown AC, Chappell LC, Goudar SS, Gidiri MF, Shennan AH; CRADLE-3 Trial Collaboration Group. Evaluation of a novel device for the management of high blood pressure and shock in pregnancy in low-resource settings: study protocol for a stepped-wedge cluster-randomised controlled trial (CRADLE-3 trial).Trials. 2018 Mar 27;19(1):206. doi: 10.1186/s13063-018-2581-z.PMID: 29587875

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Nathan HL, Boene H, Munguambe K, Sevene E, Akeju D, Adetoro OO, Charanthimath U, Bellad MB, de Greeff A, Anthony J, Hall DR, Steyn W, Vidler M, von Dadelszen P, Chappell LC, Sandall J, Shennan AH; CLIP Working Group. The CRADLE vital signs alert: qualitative evaluation of a novel device designed for use in pregnancy by healthcare workers in low-resource settings. Reprod Health. 2018 Jan 5;15(1):5. doi: 10.1186/s12978-017-0450-y. PMID:29304812

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2017

Nathan HL, Seed PT, Hezelgrave NL, De Greeff A, Lawley E, Anthony J, Hall DR, Steyn W, Chappell LC, Shennan AH. Early warning system hypertension thresholds to predict adverse outcomes in pre-eclampsia: A prospective cohort study. Pregnancy Hypertens. 2018 Apr;12:183-188. doi:10.1016/j.preghy.2017.11.003. Epub 2017 Nov 21. PMID:29175171

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2016

El Ayadi AM, Nathan HL, Seed PT, Butrick EA, Hezelgrave NL, Shennan AH, et al. (2016) Vital Sign Prediction of Adverse Maternal Outcomes in Women with Hypovolemic Shock: The Role of Shock Index. PLoS ONE 11(2): e0148729. doi:10.1371

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Nathan HL, Cottam K, Hezelgrave NL, Seed PT, Briley A, Bewley S, et al. (2016) Determination of Normal Ranges of Shock Index and Other Haemodynamic Variables in the Immediate Postpartum Period: A Cohort Study. PLoS ONE 11(12): e0168535.

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2015

Nathan H., De Greef A., Hezelgrave N., Chappell L., Shennan A. Accuracy Validation of the Microlife 3AS1-2 Blood Pressure Device in an African Pregnant Population with Low Blood Pressure. In Press. Blood Pressure Monitoring. 2015.

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Nathan HL, El Ayadi A, Hezelgrave NL, Seed P, Butrick E, Miller S, Briley A, Bewley S, Shennan AH. Shock index: an effective predictor of outcome in postpartum haemorrhage? BJOG. 2015 Jan;122(2):268-75. doi: 10.1111/1471-0528.13206. PMID: 25546050

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2014

Nathan H., de Greeff A., Hezelgrave N., Chappell L., Shennan A. An Accurate Semi-Automated Oscillometric Blood Pressure (BP) Device for Use in Pregnancy in a Low- and Middle-Income Country Population: the Microlife 3AS1-2. Blood pressure monitoring. 2014; 20(1): 52-5.

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2013

Hezelgrave N, de Greef A, Irvine L, Seed P, Radford S, Shennan A. PP058. Cradle: Community blood pressure monitoring in rural Africa: Detection of underlying pre-eclampsia. Pregnancy Hypertens. 2013 Apr;3(2):88. doi: 10.1016/j.preghy.2013.04.085. Epub 2013 Jun 6.PMID: 26105913

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2008

de Greeff A., Nathan H., Stafford N., Liu B., Shennan A.H. Development of an accurate oscillometric blood pressure device for low resource settings. Blood Press Monit. 2008 Dec;13(6):342-8. doi: 10.1097/MBP.0b013e32830fd07c.

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